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Given the composite nature of bone tissue and the intricate requirements of bone tissue engineering materials, composite materials have become the preferred choice, offering superior performance compared to single-component materials ( Polymethyl methacrylate (PMMA) bone cement is extensively used in orthopedic surgery, but the high elastic modulus and low biocompatibility have limited further advancements (Zhu et al., 2020

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Embryonic Stem Cells (ESC): Promote lifelong cell regeneration, enhancing texture and elasticity for visible anti-aging effects