Here, seeking to further improve the metabolic efficacy of GLP-1RGIPR co-agonism, we report the development of a unimolecular quintuple agonist that combines the body weight-reducing and blood glucose-lowering effects of GLP-1RGIPR co-agonism with the insulin-sensitizing and anti-inflammatory effects of lanifibranor via its targeted delivery into GLP-1R- and GIPR-expressing cells
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Vielversprechend ist auch der duale GLP-1/GIP-Agonist Tirzepatid bezglich seiner Effekte bei Patienten mit Adipositas unabhngig von T2DM (30)
GLP-1 receptor agonists (GLP-1RAs) are widely used in the treatment of type 2 diabetes (T2DM) due to their attributes such as body weight loss, protection of islet cells, promotion of islet cell proliferation and minimal side effects
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