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mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase

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Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis

Proteins were detected using the following antibodies: Lyn PerCP (clone C13F9, Cell Signaling Technology), SYK PE (clone B435666, Biolegend), PLC2 AF488 (clone K86-1161, BD Biosciences), pan AKT APC (Miltenyi Biotec), and S6 AF700 (clone 54D2, Cell Signaling Technologies)

Inhibition of TRF1 telomere protein impairs tumor initiation and progression in glioblastoma mouse models and patient-derived xenografts

The result slower skin cell turnover, reduced collagen synthesis, weaker repair response to sun damage and environmental stress is what most people notice as the first signs of aging