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Proc Natl Acad Sci U S A 103(12):47414746

The evidence base consistently demonstrates that modest caloric restriction combined with regular exercise produces clinically significant weight loss and improves metabolic health markers

These findings are uncertain in populations with low cortisol levels [160], but they appear to exist in populations with high or moderate levels of cortisol [6, 28, 29, 138, 161]

These are solid scientific findings from reputable institutions published in peer-reviewed journals

246 Despite these promising results, liver-targeting specificity remains uncertain, and large-scale clinical validation is lacking