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110,111 Preclinical data indicate that SIRT1 activators, such as resveratrol and SRT1720, improve insulin tolerance by activating the AMPK/IRS-1/Akt pathway, inhibiting FOXO1, 112 and downregulating phosphoenolpyruvate carboxykinase and glucose-6-phosphatase expression

PASC could encompass several adverse clinical impairments that may trigger chronic metabolic dysfunctions involving cardiovascular (CV), central/peripheral nervous (CNS/PNS), gastrointestinal (GI), pulmonary, reproductive, skeleto-muscular, and endocrinal systems 6,7

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