Patients in tirzepatide trials lost 515% of baseline body weight by week 12, with continued loss through week 52
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Interview Studying how genomes stay intact July 20, 2026 Patrick OBrien discusses DNA repair, enzyme evolution, scientific publishing and mentorship, reflecting on the curiosity-driven questions that shaped his career and his approach as a JBC associate editor
The STEP 5 trial indicated that most participants achieved considerable and sustained reductions over a 104-week period
These genetic predispositions do not determine exact medication response, but they may provide clinical context for provider decision-making and help explain why treatment outcomes vary across patients with similar starting profiles
It typically resolves within 6 to 12 months once weight and nutrition stabilize