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In studies focusing on Polish patients with AMD, mutations in GPx1 were found, and these mutations lead to weaker antioxidant defense

Xu SL, Shrestha R, Karunadasa SS, Xie PQ

Knockdown of each transporter reduced 54 Mn uptake into the cells

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In addition, the p62-Keap1-NRF2 32 , ATG5-ATG7-NCOA4 33 , and glutamine metabolic pathways 25 can effectively regulate the formation of intracellular iron ions and ROS and play a regulatory role in ferroptosis (Fig