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(2023) Int J Mol Sci, 24

As will be further discussed in section Aging and age retaled diseases, IGF-I and GH levels also decrease with aging (somatopause)[169], reason why a potential strategy for reversing these senile changes in thymic vitality may involve administration of either GH or IGF-I, which have been examined for their potential to expand T-cell populations in animals[170]

Furthermore, to sustain the conversion of pyruvate to acetyl-CoA and its entry in the TCA cycle, due to the lack of glutamate induced by GLS1 knockdown, it implies the activation of other metabolic pathways

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For instance, vitamin A (an in vivo product derived mainly from -carotene) is an excellent scavenger of singlet oxygen, blocking and/or reverting lipid peroxidation in the plasma membrane (Sies and Stahl, 1995