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Binding, agonism, internalization, and -arrestin recruitment Studies published by 49 and 48 have documented the physiologic relevance of internalization and -arrestin recruitment in response to specific interactions with both the GLP-1R and Y2-R 49 demonstrated that the extent of internalization and receptor trafficking mediated by Ex-4 (the scaffold upon which GEP44 is built) has a direct impact on the ISR and that efforts to retain GLP-1R on the cell surface result in enhanced and sustained insulin release

Average decreases in folic acid concentrations of 36% (dark) and 39% (light) after 6 months and 47% (dark) and 50% (light) after 12 months of storage were observed 487

Cell Signal 82 , 109972 (2021)

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In: Bonanthaya, K., Panneerselvam, E., Manuel, S., Kumar, V.V., Rai, A