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558 demonstrated that overexpression of the Drosophila homolog of human ZIP1 leads to zinc accumulation in A42-expressing fly brains, and inhibition of ZIP1 expression reduces A42 fibril deposits and improves cognition 16

HS conceived the original design of the studies

596,597,598 Research of both HSV1-infected mice and AD mouse models has revealed the gene MAM domain containing 2 (MAMDC2) exhibits significant expression in microglia, which results in high levels of I-IFNs to enhance antiviral responses in HSV1-infected mice and neuroinflammation in the AD animal model

These pleiotropic effects could position tirzepatide as an emerging therapeutic option for individuals with T2D and to address a broader spectrum of metabolic disorders (Fig

Dec 1984;79(12):941-944

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