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Flavonols with the 3-hydroxyl group, the 4-keto group, and the 2,3-double bond with the catecholic B-ring are strong chelators at neutral and slightly acidic pH levels, and flavonoids with the 5-hydroxyl-4-keto chelation site are weaker chelators even at neutral pH

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The approval validated years of preclinical research and opened the door for subsequent generations of GLP-1 drugs with improved efficacy and convenience profiles

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