Rodrguez-Nieto et al., 2022)
Over-the-counter retinol has a weaker dataset than its prescription counterpart, but the mechanistic evidence is solid
Excessive ROS levels can induce cellular damage, initiating a cascade of effects that potentially culminate in tissue and organ injury ( 3.1.1 Impact of ROS on cellular function and atherosclerosis Elevated ROS can induce endothelial cell dysfunction or death, disrupting the vascular barrier and leading to vasoconstrictive and vasodilatory dysfunction, vascular smooth muscle cell proliferation and migration, inflammatory responses, and thrombosisprocesses intimately associated with various cardiovascular disorders, including atherosclerosis, hypertension, and CHD (31)
S., Gmez-Rivera, E., & Ortiz-Prado, E
PMID 39963574
A US-based CHB cohort identified increasing age and male sex as strong predictors of HCC