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This dual approach addresses both insulin resistance (via metformin) and appetite regulation plus incretin signaling (via semaglutide), creating a more comprehensive metabolic intervention

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With proper support in lifestyle modifications (especially diet and exercise) many patients could successfully reverse prediabetes without pharmacological intervention

*Correspondence: Jocelyn R

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The drug also normalized the levels of glucose transporters like glucose transporter type 1 (GLUT1), glucose transporter type 3 (GLUT3), and glucose transporter type 4 (GLUT4), which are critical for neuronal energy supply