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Renal Function and Dialysis Research Kidney disease profoundly affects L-Carnitine homeostasis, creating a research area at the intersection of renal physiology and metabolism: Renal Carnitine Handling: Investigation of tubular reabsorption via OCTN2, urinary excretion patterns, and renal threshold determinations

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Variants such as GLP1R rs6923761 and GIPR rs1800437 may correlate with baseline GLP-1 sensitivity and appetite-regulation capacity

In the STEP and SELECT trials ( Lancet Diabetes & Endocrinology , 2024), weight typically stabilised after an initial steep drop and then declined more slowly

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