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Gonzalez A, Estaras M, Martinez-Morcillo S, et al

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Free Radic Biol Med 29:124

Although the mechanisms linking GLP-1 receptor activation to blood pressure control require further investigation in humans, GLP-1RAs have been shown to lower blood pressure by augmenting natriuresis and diuresis, which are mainly mediated by their inhibition of the Na + /H + exchanger isoform 3, located at the brush border of the renal proximal tubule [23]