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Our major objective is to identify cancer driver genes and oncogenic pathways induced by CR-related perturbation of cellular homeostasis affecting normal proliferation of epithelium mucosa via metabolic reprogramming and depletion of immune system control

it functions as a potent steroid hormone that regulates the expression of hundreds of genes, particularly those involved in immune function

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In healthy individuals, the immune system learns early in life to tolerate the body own tissues

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