If the research supports a regulatory application, requests will be considered after the product, and its intended use are approved in both the EU and the USA
Formation of hexa- and decadepsipeptides via NRPS misoperation is key to form the isocereulides E, F and G, whereas peptide assembly in the biosynthesis of isocereulides A-D corresponds well to that of cereulide differing that L- O -Val is substituted by L- O -Leu (isocereulide A), L-Val by L-Ala (isocereulide D), D-Ala by D-Ser (isocereulide C) and D-O-Leu by D-O-Val (isocereulide B) due to a relaxed substrate specificity of the A domains and/or an inefficient proof reading by CesT
1988 Feb;99(2):143-54
Final concentration will depend on vial dosage and the specific research application
These investigations prioritize understanding the molecular integration of energy-balance markers and signal-relay patterns, with all findings remaining strictly pre-clinical and exploratory
David Aberg N, Lind J, Isgaard J, Georg Kuhn H
