It's worth noting that long-term cardiovascular outcome trials for Mounjaro are ongoing, and cardiovascular risk reduction is not currently established in UK licensing
Weight regain after GLP-1 discontinuation happens because the underlying biological driversinsulin resistance, excess appetite hormones, and metabolic rate changesremain untreated
In mice, GLP-1R are found in several areas including the circumventricular organs, the amygdala and hypothalamic nuclei 5
10.1016/S1474-4422(21)00465-8 62 GregoryJ
These dynamic transitions align with the heterogeneity observed in microglia isolated from postmortem brain tissue of AD patients [42]
It showed that the relative risks for aspiration, aspiration pneumonia, pneumonia, or respiratory failure were not elevated in patients prescribed GLP-1 RA compared to those receiving dipeptidylpeptidase-4 (DPP-4) inhibitors [21]