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Catucci G, Querio G, Sadeghi SJ, et al

While the published study focused primarily on SGLT2is and reported improvements in DHEAS and menstrual irregularity, our meta-analysis included a broader range of interventions (GLP-1 RAs alone and in combination) and found more pronounced hormonal benefits, such as significant reductions in FAI and testosterone with SGLT2is, outperforming GLP-1 RAs in these aspects

The animals used in the study were consistently between four and six months of age, ensuring developmental consistency across experimental groups [1]

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Among them, synovial macrophages (SMs) are known as the most prominent cells responsible for lesion formation and aggravation