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Regarding the underlying mechanism, IR in the brain significantly contributes to neurodegenerative processes, and GLP-1RAs modulate downstream signaling pathways, including mitochondrial biogenesis, autophagy, inflammation, and cell survival
According to NICE guidance, GLP-1 receptor agonists are recommended for specific patient groups with type 2 diabetes (NG28) and, in some formulations like Wegovy (semaglutide 2.4mg) and Saxenda (liraglutide 3mg), for weight management in adults with obesity or overweight with weight-related comorbidities
[DOI] [PMC free article] [PubMed] [Google Scholar] El-Tawil OS, Abou-Hadeed AH, El-Bab MF, Shalaby AA
The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats: some behavioral, biochemical, and histopathological studies
Observational Data and Real-World Use In the absence of direct clinical trials on pregnant individuals, some data comes from observational studies
