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Keywords: Tirzepatide, GLP-1, Glucose-dependent insulinotropic peptide, Cardiovascular risk factors INTRODUCTION Tirzepatide is a synthetic peptide composed of 39 amino acids, which functions as a dual receptor agonist (RA) binding both the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors and this unique mechanism of action resulted in the nickname twincretin. The structure of tirzepatide is based on that of the native GIP with the addition of a 20-carbon fatty diacid moiety, which increases its half-life to 5 days allowing for once-weekly administration

When there is too much inflammation in the brain, it can affect how well brain cells communicate, potentially leading to mood and behavioral changes

However, the clinical translation of Kla-targeted therapies faces notable challenges, including the lack of specific inhibitors, potential off-target effects and the complex tissue-specific functions of lactylation

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Arthritis Res Ther (2020) 22(1):116

Now, this can be done safely without hospitalization, but it needs a team approach