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Plekratoke, K

Oral GLP-1s create a pathway to manage cost and scale access, but next-gen injectables will continue to reset the clinical ceiling (and member expectations)

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It is important not to exceed the recommended daily dose

reported that tirzepatide stimulates cAMP accumulation with an efficacy similar to native GIP but weaker than GLP-1 in cell lines expressing recombinant GLP-1R and GIP-R in vitro (28)