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The specific thresholds that should prompt dose reduction or discontinuation include: ALT or AST elevation exceeding 3 times the patient's baseline value, new or worsening coagulopathy (INR increase of 0.5 or more from baseline), albumin decline below 2.5 g/dL, or new clinical signs of hepatic decompensation such as worsening ascites, encephalopathy, or jaundice [5]

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In one animal study, eurycomanone was shown to improve fertility by increasing sperm production

doi:10.1016/j.beem.2018.06.007 Wilding JPH, Batterham RL, Calanna S, et al

2005;153(3):R7-R10

Angelova PR, Abramov AY (2018) Role of mitochondrial ROS in the brain: from physiology to neurodegeneration