The agency cited immunogenicity concerns, saying there was limited data on the quality, stability and consistency of the compounds
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Where most therapeutic peptides degrade within minutes under simulated gastric or intestinal conditions, BPC-157 retains its integrity in human gastric juice for more than 24 hours, tolerates a wide pH range, and resists multiple proteolytic enzymes including pepsin and trypsin
The most likely explanation relates to metabolic changes induced by these medications
The only issue will be long term sustainability
Cell Host Microbe 7:290301 Zhang J, Shao F, Li Y, Cui H, Chen L, Li H, Zou Y, Long C, Lan L, Chai J (2007) A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants