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Under homeostatic conditions, NRF2 is sequestered in the cytoplasm through its interaction with the repressor protein KEAP1

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10.1210/jc.2004-1476 J

Its one of those rare compounds that touches almost every system in your body from your brain and liver to your lungs and skin

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This is however controversial and astrocytic morphology changes are not always seen [67, 80]