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Journal of the Medical Library Association

In contrast, protective metabolites [e.g., short-chain fatty acids (SCFAs), bile acid (BA), hydrogen sulfide (HS), and indole derivatives] offer compensatory protection through opposing pathways, including anti-inflammatory effects, antioxidant activity, and maintenance of metabolic homeostasis

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They usually appear after bouts of constipation, hard stools, diarrhea, or inflammation