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Most B12 supplements deliver cyanocobalamin a synthetic form that requires the body to convert it into methylcobalamin before it can be used

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PMID: 14648529

49 There is insufficient evidence to support a more intensive screening program

A balanced diet and the ability to absorb specific nutrients such as vitamins B2, B6, Folate and B12, C, D, zinc, choline, betaine, methionine and cysteine are important to the healthy function of the methionine cycle, but this list is not exhaustive