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Immune dysregulation in both innate and adaptive immune systems can impact the activation and progression of SLE (1, 6)

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Oxidative stress and preeclampsia: Rationale for antioxidant clinical trials

Surprisingly, when an antioxidant combination of 1,000 mg of vitamin C, 800 IU (536 mg) of RRR --tocopherol, 100 g of selenium, and 25 mg of -carotene daily, was taken with the simvastatin-niacin combination, the protective effects were diminished