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Previous studies have shown that internalization of these receptors following ligand stimulation is more pronounced in IR than IGF1R (14), and this effect is decreased in insulin-resistant obese subjects and obese type 2 diabetic patients (24)

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Acta Orthop Scand 71:316321 Ethics declarations Conflict of interest The authors declare that they have no conflict of interest

Mithieux G, Misery P, Magnan C, Pillot B, Gautier-Stein A, Bernard C, et al