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In addition to the ASO, the efficacy of an RNAi directed at PNPLA3, known as LY3849891, is also being evaluated in clinical trials for patients with MASH with PNPLA3 variants (NCT05395481) 64

PH: Conceptualization, Supervision, Writing original draft, Writing review and editing

One study demonstrated that GLP-1 can activate LTP in the brain and ameliorate cognitive dysfunction in a neurodegenerative disorder model (McClean et al., 2011)

Lastly, its essential to moderate the intake of foods and substances that can irritate the gastrointestinal tract or contribute to constipation, such as caffeinated drinks, alcohol, spicy foods, and processed foods

The STAT6-ANGPTL4 axis may be directly or indirectly associated with activation of the cGAS-STING pathway, macrophage polarization, and macrophage-to-mesenchymal transition in the diabetic kidney, thereby promoting renal fibrosis

Long-term planning for maintenance and weight regain The framework is in the visual