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A critical mechanism involves maintaining the mature -cell phenotype through the regulation of key transcription factors, including pancreatic duodenal homeobox-1 (PDX1), MAF BZIP transcription factor A (MAFA), and NKX6.1 [56,57]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Skvarc D.R., Dean O.M., Byrne L.K., Gray L., Lane S., Lewis M., Fernandes B.S., Berk M., Marriott A

To view or add a comment, sign in New AusPAR for Adzynma is a recombinant ADAMTS13 enzyme replacement therapy that has been approved for the treatment of ADAMTS13 deficiency in patients with congenital thrombotic thrombocytopenic purpura (cTTP)