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Note on humans: These benefits are not established in humans the evidence is mostly older Russian and preclinical work with limited independent replication [13]

GDF15 also acts centrally via the glial cell-derived neurotrophic factor family receptor alpha-like (GFRAL), potentially contributing to symptoms like fatigue, nausea, and stress in FM 30,31,32,33,34

Blood sugar remains stable, appetite stays controlled, fat mobilization increases, and muscle protein synthesis continues despite reduced caloric intake