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Diagnostics (Basel) 2024;14:2829.ArticlePubMedPMC 7

[Accessed 16th April 2026]

Research has found that after high glucose and high fat culture in vitro , the expression of Pdx1 in primary pancreatic islets decreases, intervention with liraglutide can significantly increase the secretion of Pdx1, while GLP-1R inhibitors can counteract this effect (Cataldo et al., 2021)

Those who shouldnt take GLP-1 agonists include people who: are pregnant, nursing, or planning to become pregnant have a history of thyroid cancer or pancreatitis are allergic or sensitive to any of the GLP-1 medications have multiple endocrine neoplasia (MEN) syndrome type 2 Weight loss medications are not recommended for people with past or active eating disorders

Discuss any persistent GI distress with your provider

The Best GLP-1 Injection Sites Choosing the right spot is the easiest way to keep injections comfortable and effective