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In both cases, Epitalon significantly enhanced telomerase activity, directly contributing to telomere elongation during the G1 phase of the cell cycle [ 25 ] [26 ]

These alterations are linked to the loss of vascular smooth muscle cell contractile ability, which is related to increased reactive oxygen species levels and decreased adenosine triphosphate generation [80]

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If the GLP-1/GIP/glucagon receptor class shows disease-modifying behaviour in OA rather than just mechanical pain relief from weight loss, it expands the scientific rationale for the compound and reinforces the argument that the triple-agonist mechanism is doing more than suppressing appetite