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This process is particularly pronounced when glutathione (GSH) is depleted or glutathione peroxidase 4 (GPX4), a key enzyme that prevents lipid oxidation, is inhibited [39]

In some embodiments, the ratio of a thermoreversible poloxamer to a thickening agent in a formulation that has a pH as described herein is about 40:1, about 35:1, about 30:1, about 25:1, about 20:1, about 15:1, about 10:1, or about 5:1

Interleukin-15 Stimulates Macrophages to Activate CD4+ T Cells: A Role in the Pathogenesis of Rheumatoid Arthritis