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Peptides were eluted over 60 min using a binary buffer system consisting of buffer A (0.1% formic acid) and buffer B (80% ACN, 0.1% formic acid)

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On-Therapy Monitoring Schedule Weeks 4 and 8: IGF-1, ALT, AST, albumin, fasting glucose, body weight Week 12: Full CMP, IGF-1, HbA1c, PT/INR, Child-Pugh re-score Every 3 months thereafter: IGF-1, liver panel, albumin Target IGF-1 in the mid-normal range for age and sex