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In the nigrostriatal tract system, dopamine undergoes autooxidation or oxidative deamination by monoamine oxidase-B, both of which aggravates with age, leading to increased production of peroxides and hydroxyl radicals 41

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Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

Cytosolic AceCS (encoded by the ACSS2 gene) is a target of cytoplasmic SIRT1 whereas, mitochondrial AceCS (encoded by the ACSS1 gene) is a target of mitochondrial SIRT3

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