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Semaglutide has a slightly better serious adverse event rate in comparative data, and its GLP-1-only mechanism tends to produce somewhat less pronounced appetite suppression

D.JedrychowskiM.VidoniS.KitaseY.BhattR.et al (2018)

However, many innovative therapies, ranging from molecularly targeted drugs to regenerative cell and gene therapies, are under investigation [70]

Understanding the translation from trials to practice helps set appropriate expectations

The GLP-1 receptor activation works by reducing appetite and slowing gastric emptying, helping patients feel fuller for longer periods and naturally reducing calorie intake