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Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)

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Passos, P

10.1016/j.atherosclerosis.2010.05.028 Atherosclerosis 147 SchwartzS

Ingredient-level citations are attributed to the ingredient - not used as proxies for whole-product outcome claims

Yu, K.-F