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A major limitation is that most available evidence is based on preclinical studies, while rigorously designed human clinical trials remain limited

Taking into account available data concerning the alkylating nature of ethylene oxide, the demonstration of DNA adducts, the overwhelming positive in vivo responses in mutagenic and clastogenic assays, the reproducible positive carcinogenic findings in animals, and the epidemiological findings suggesting an increase in the incidence of human cancer, ethylene oxide should be considered as a probable human carcinogen, and its levels in the environment should be kept as low as feasible

3 However, age is the most important risk factor

The process according to claim 9, wherein the dissolution in water is carried out under stirring by means of high shear stirrers

(2022) N-acetylcysteine: A review of clinical use and efficacy

Nat Commun (2021) 12(1):1589