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While most patients tolerate B12 shots well, mild side effects can occasionally occur, including minor pain or redness at the injection site, mild diarrhoea, or, in rare instances, an allergic reaction

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The high is the best and most recommended region on the body for anyone that is self-administering a B12 shot

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Acneiform or skin changes have been reported with high-dose or frequent B12 administration, though the mechanism remains unclear