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Tanford, 1968]

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Potential risks may include immunogenicity or impurities

So far, there are no published randomized, controlled trials investigating pharmacological treatment options for fluid intake in primary polydipsia

The expected pattern of pharmacokinetic changes is also found in pediatric patients taking other antiepileptic drugs that are hepatic enzyme inducers (phenytoin, carbamazepine, phenobarbital, primidone: lamotrigine clearance = 3.6 mL/min/kg, lamotrigine half-life = 8 hours) or hepatic enzyme inhibitors (valproate: lamotrigine clearance = 0.47 mL/min/kg, lamotrigine half-life = 45 hours)

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