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Conversely, intraperitoneal administration of vitamin E at a dose of 500 mg/kg to diabetic rats resulted in a non-significant increase in SOD activity, while GSH levels exhibited non-significant decrease in both the blood and liver tissue

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Thus, melanin possesses both antioxidant and ROS-dependent cytotoxic properties[18]

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The examination of a patient with numerous pigmented lesions can be challenging for both novice and experienced clinicians