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LTP: Long-Term Potentiation

The rest period allows receptor populations to reset

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Specifically, phosphorylation of CARM1 at S217 by unknown kinase(s) blocks the binding of SAM to the catalytic site, whereas phosphorylation at S228, possibly by protein kinase C (PKC), disrupts CARM1's dimerization, ultimately restricting its methyltransferase activity during mitosis or dendritic maturation [91-93]