Clearly, mAb1-bound GCGR is unable to assume the closed conformation observed in the Fab7F38GLP-1R structure
That is the signature of cumulative collagen response: no single dramatic event, just gradual improvement that compounds over time
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Furthermore, the fold change from baseline (0 h) to the individual maximum TMAO concentrations showed no significant difference between interventions (mean fold change difference [95% CI]: 0.26 [ 1.4, 0.80], p -value = 0.26)