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Tolosa et al., 2013

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FIGURE 6 12 Concluding remarks and future research In summary, metabolic dysfunction in T2DM affects insulin receptor signaling, inhibiting the PI3K-Akt cascade and enhancing GSK3 hyperactivity, NAD + depletion, and Sirt1/Sirt3 inactivation

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The scientists cautioned that this new research is still in the early stages, and they have yet to determine what these changes mean, and how they might impact the brain long term