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Quality of evidence: II-B, Strength of recommendation: 1 Panel level of agreement: In total agreement 100% ACLF is a dynamic syndrome that involves prognostic scores for making the diagnosis

DISCUSSION In this NMA, GLP-1RA had a significantly better effect in reducing liver fat content and improving cardiometabolic risk parameters, including BMI and WC, in overweight or obese patients with NAFLD or NASH

[12] [13] Improved glycaemic control : By enhancing insulin secretion in response to food and reducing glucagon release, semaglutide helps stabilise blood sugar levels

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However, these mechanisms remain speculative in human RA and require validation through dedicated clinical trials

I was sleeping better, my knees felt great walking stairs, and my bloodwork came back with improved triglycerides and fasting glucose