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& Alvarez, B

Studies have shown that people taking GLP-1 receptor agonists for weight loss can experience a significant reduction in body weight, with some losing a significant percentage of their initial body weight over time

The clinical implications for timeline are meaningful

For individuals with obesity, adjusted body weight can also be used to determine daily protein needs, and is calculated as target body weight plus 25% of the difference between current and target body weight

J Appl Physiol (1985) 110(3):774780 Chang CH, Tsai WC, Hsu YH, Pang JH (2014) Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts

This is why, without ongoing resistance training or other forms of mechanical load , muscle that once served to support higher body weight will naturally diminish when that weight and its mechanical demand are gone