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3D: three-dimensional ACE2: angiotensin-converting enzyme 2 AI: artificial intelligence AMPs: antimicrobial peptides Arg: arginine Asp: aspartic acid ATG16L1: autophagy related 16 like 1 gene BCL-2: B-cell lymphoma-2 CuAAC: copper(I)-catalyzed azidealkyne cycloaddition eIF4E: eukaryotic initiation factor 4E Fmoc: 9-fluorenylmethyloxycarbonyl FOXP3: forkhead box protein P3 GLP-1: glucagon-like peptide 1 GLP-1R: glucagon-like peptide 1 receptor Glu: glutamic acid hACE2: human angiotensin-converting enzyme 2 HCS: hydrocarbon-stapled His: histidine KRAS: Kirsten rat sarcoma viral oncogene homolog Lys: lysine MafG: musculoaponeurotic fibrosarcoma homolog G Mag2: magainin II MAML1: mastermind-like transcriptional coactivator 1 MC1R: melanocortin 1 receptor Mcl-1: myeloid cell leukemia-1 MDM2: murine double minute 2 NC: net charge NLS: nuclear localization signal Nrf2: nuclear respiratory factor PDB: Protein Data Bank PEG: polyethylene glycol PPIs: protein-protein interactions RCM: ring-closing metathesis RpoN: RNA polymerase sigma-54 factor SAH: stapled -helical SARS-CoV-2: severe acute respiratory syndrome coronavirus 2 SMoCs: small molecule carriers SPPS: solid-phase peptide synthesis StAMP: stapled antimicrobial peptide STRs: synthetic transcriptional repressors Syt1: synaptotagmin-1 Tat: trans-acting activator of transcription TF: transcription factor Treg: regulatory T UV: ultraviolet WASF: Wiskott-Aldrich syndrome protein family WT: wild type QZ and ZW equally contributed to: Conceptualization, Investigation, Writingoriginal draft, Writingreview & editing

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