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And GLP-1 peptide drugs like semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro and Zepbound) have undergone extensive testing in clinical trials to become FDA-approved drugs for obesity and type 2 diabetes

It remains to be investigated whether cardiovascular protective effects of GLP-1RAs can also be independent of the known effects on glucose metabolism

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Shepherd, BMI is one key factor in determining eligibility, with most participants having a BMI of 30 or higher

Retrieved February 22, 2023, from us.com/products/product-supply-update.html Putka, S

Taken together, evidence from the STEP, SURMOUNT, and S-LiTE trials strongly supports the lifestyle interventions, particularly dietary modification and structured exercise, being not only compatible with but also additive to the effects of GLP-1 therapies